Due to the COVID 19 epidemic, orders may be processed with a slight delay

Search

In Stock

Morphine Tablets IP – Numorf-30 from UK to UK

Active ingredient Morphine
Producer Bio Swizz
Treatment Pain relief
Shipping Origin UK
Packaging Blister

 

$399.00$1,799.00

Clear
Compare

Description

Morphine is an opioid agonist used for the relief of moderate to severe acute and chronic pain. Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as codeine, fentanyl, methadone, hydrocodone, hydromorphone, meperidine, and oxycodone.
Opiods, including morphine, are effective for the short term management of pain. Patients taking opioids long term may need to be monitored for the development of physical dependence, addiction disorder, and drug abuse.
Avoid alcohol. Concomitant use may lead to profound sedation, respiratory depression, coma, and death. Take with or without food. There is no significant different in the AUC or Cmax of oral extended release tablets when taken with or without food.

Pharmacodynamics

Morphine binding to opioid receptors blocks transmission of nociceptive signals, signals pain-modulating neurons in the spinal cord, and inhibits primary afferent nociceptors to the dorsal horn sensory projection cells.
Morphine has a time to onset of 6-30 minutes. Excess consumption of morphine and other opioids can lead to changes in synaptic neuroplasticity, including changes in neuron density, changes at postsynaptic sites, and changes at dendritic terminals.
Intravenous morphine’s analgesic effect is sex dependent. The EC50 in men is 76ng/mL and in women is 22ng/mL. Morphine-6-glucuronide is 22 times less potent than morphine in eliciting pupil constriction.

Mechanism of action

Morphine-6-glucuronide is responsible for approximately 85% of the response observed by morphine administration. Morphine and its metabolites act as agonists of the mu and kappa opioid receptors.
The mu-opioid receptor is integral to morphine’s effects on the ventral tegmental area of the brain. Morphine’s activation of the reward pathway is mediated by agonism of the delta-opioid receptor in the nucleus accumbens, while modification of the respiratory system and addiction disorder are mediated by agonism of the mu-opioid receptor.

Metabolism

Metabolism: Morphine is 90% metabolized by glucuronidation by UGT2B7 and sulfation at positions 3 and 6. Morphine can also be metabolized to codeine, normorphine, and morphine ethereal sulfate.
Absorption: Morphine is absorbed in the alkaline environments of the upper intestine and rectal mucosa. The bioavailability of morphine is 80-100%. There is significant first-pass metabolism, therefore oral doses are 6 times larger than parenteral doses to achieve the same effect. Morphine reaches steady-state concentrations after 24-48 hours. Parenteral morphine has a Tmax of 15 minutes and oral morphine has a Tmax of 90 minutes, with a Cmax of 283nmol/L. The AUC of morphine is 225-290nmol*h/L.
Route of elimination: 70-80% of an administered dose is excreted within 48 hours. Morphine is predominantly eliminated in the urine with 2-10% of a dose recovered as the unchanged parent drug. 7-10% of a dose of morphine is eliminated in the feces.
Half life: Morphine has a half life of 2-3 hours.

Side effects

All medicines may cause side effects, but many people have no, or minor, side effects. Some medical conditions may interact with Morphine.Tell your doctor or pharmacist if you have any medical conditions.Patients experiencing an overdose present with respiratory depression, somnolence, skeletal muscle flaccidity, cold and clammy skin, miosis, and mydriasis. Symptoms of overdose can progress to pulmonary edema, bradycardia, hypotension, cardiac arrest, and death. Treat overdose with symptomatic and supportive treatment which may include the use of oxygen, vasopressors, and naloxone.This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

Reviews

There are no reviews yet.

Write a review

Your email address will not be published. Required fields are marked *

Bestsellers

Pregabalin HAB Pharma - Lyrica 300mg from Netherlands to Europe

$114.00$864.00
(1 Review)
Active ingredient Pregabalin Producer HAB Pharma Treatment Pain relief Shipping Origin Netherlands Packaging Blister  

Ambien Hemofarm - Belbien 10mg from Slovenia worldwide

$156.00$1,116.00
(2 Reviews)
Active ingredient Zolpidem Producer Hemofarm Treatment Sleeping Disorders Shipping Origin Slovenia Packaging Blister  

Ambien Lek - Sanval 10mg from Slovenia worldwide

$195.00$1,512.00
(3 Reviews)
Active ingredient Zolpidem Producer Lek Treatment Sleeping Disorders Shipping Origin Slovenia Packaging Blister  

Valium Roche - Diazepam 10mg from USA to USA

$165.00$1,224.00
(3 Reviews)
Active ingredient Diazepam Producer Roche Treatment Insomnia Shipping Origin USA Packaging Loose  

Tramadol Alkaloid - Tramadol HCL 50mg from Slovenia worldwide

$144.00$1,008.00
(1 Review)
Active ingredient Tramadol Producer Alkaloid Treatment Pain relief Shipping Origin Slovenia Packaging Blister  

Pregabalin HAB Pharma - Lyrica 300mg from Netherlands worldwide

$114.00$864.00
(1 Review)
Active ingredient Pregabalin Producer HAB Pharma Treatment Pain relief Shipping Origin Netherlands Packaging Blister  

Back to Top
Product has been added to your cart